CognitionWall

cognitionwallThe CognitionWall™ was designed for the development of operant cognitive tests in PhenoTyper® home-cages. The CognitionWall is a wall with three entrances, which is placed in front of the reward dispenser. Combined with real-time video tracking in Ethovision to drive the reward dispenser, it forms the basis for operant cognitive tasks developed by Sylics.

Cognitive tests based on the CognitionWall™

CognitionWall Discrimination learning:

  • Validated with pharmacological (e.g. MK-801) and genetic models (e.g. APP/PS1 Alzheimer’s disease model)
  • High-throughput cognitive testing: Our 1-night protocol is more sensitive than a conventional 7-day Morris water maze

CognitionWall Reversal learning (cognitive flexibility):

  • Validated with lesions of the orbitofrontal cortex, a brain region implicated in cognitive flexibility
  • Sensitive task for detection of subtle cognitive impairments in genetic models

discrimination-learning

Take advantage of automated cognitive testing

Contact us if you are interested in implementing operant cognitive testing using the CognitionWall in your facility.

The CognitionWall is available through Noldus Information Technology.

Our publications on CognitionWall cognitive tests

1Cognitive flexibility deficits in a mouse model for the absence of full-length dystrophin. Remmelink, Loos et al., Genes Brain Behav. 2016; 15:558