News

> March 2017

Sylics presents automated behavioural screening tools at AD/PD 2017

Together with our partner Noldus, we will showcase tools for automated behavioural screening at the AD/PD 2017 in Vienna (March 29-April 2). These include automated tests targeting different behavioural domains in rodents, including cognition, anxiety and motor function. Sylics will also present cloud-based data storage, analysis and visualisation tools for data acquired with PhenoTyper automated home cages. We are convinced that the automated capturing and analysis of data enhances the quality of preclinical data. You can find us in booth #23 and at poster board #101.

> December 2016

AHCODA chosen as data analysis platform by EU-AIMS consortium

Our AHCODA platform will be used for storage, analysis and comparison of rat behavioural data acquired within EU-AIMS, an extensive European research project with the aim to find new methods for the development of drugs for autism spectrum disorder. To facilitate standardized analysis of a broad range of behavioural parameters and easy comparison of data from different test sites, EU-AIMS partners will use AHCODA for analysis of specific datasets. We look forward to contribute to this project.

> November 2016

Sylics’ AHCODA database wins the Dutch Data Prize

We are proud to announce that our AHCODA-DB won the Dutch Data Prize in the category medical and life sciences. Our public database, holding published as well as unpublished behavioural data of dozens of mouse strains and mutants obtained in publically funded research projects, was appreciated for its very rich dataset, excellent interface, and pioneering role in data sharing.

Ten years of development of AHCODA, paralleled by behavioural testing of over 100 mouse lines, yielded this multifunctional platform for the analysis of rodent behaviour (testing protocols, database and cloud-based analysis software). AHCODA automates data analysis, allows meta-analyses across sites, studies and models, and generates graphs and statistical analyses of datasets of interest in a matter of seconds.

ahcoda-workflow

> October 2016

New publication: CognitionWall discrimination and reversal learning

Automation can greatly benefit standardization and efficiency of behavioural testing. Our recent paper in Learning & Memory describes the assessment of discrimination learning and cognitive flexibility without prior food restriction, extended training periods and labor-intensive animal handling, using models of synaptic dysfunction, cognitive decline and cognitive inflexibility. Sylics can help you set up automated behavioural screening in your facility, or perform these experiments for you for example as part of in vivo efficacy studies.

cognitionwall-tests

> September 2016

Sylics presents automated behavioural screening tools at SfN 2016

Together with our partner Noldus, Sylics will showcase tools for automated behavioural screening at the upcoming Society for Neuroscience in San Diego. These include highly optimized automated tests to assess cognition, anxiety and motor function in rodents, as well as cloud-based data storage, analysis and visualisation tools for data acquired with PhenoTyper automated home cages. You can find us in booth 1029.

Rodents on the loose! Find them all!

There are some mice and rats on the loose at Neuroscience 2016… You can find nine magnets at a select group of partners, so visit our booths to collect them all and take this fun family home with you! Once you have all 9, take a picture and post on Twitter or Instagram with #SfN16 and #partnersinneuroscience for a chance to win an iPad!

magnets-sfn2016

> September 2016

AHCODA tools for behavioural screening nominated for Dutch data prize

We are proud that our AHCODA database, consisting of behavioural profiles of many mouse strains and mutant mouse lines, is chosen as one of the three finalists in the category “Medical and life sciences” of the Dutch data prize, awarded by SURFsara. Winners will be announced later this year.

> September 2016

LSH-FES symposia on November 23rd

The innovative work of NeuroBasic and five other research consortia of the LSH-FES program will be presented at a symposium in the Beatrix Building of Jaarbeurs Utrecht, on November 23rd. Within the NeuroBasic consortium, Sylics set up a number of novel automated behavioural tests and collected behavioural profiles of many mouse lines and compounds using its tools for automated behavioural screening.

> June 2016

Sylics attends the 17th International Conference on Alzheimer’s Drug Discovery

On 12-13 September, Sylics is present at the International Conference on Alzheimer’s Drug Discovery in Jersey City, NJ.

> April 2016

Sylics attends BIO Spring, ADDF Drug Discovery for Neurodegeneration conference and BIO Convention 2016

Delegates of Sylics are present at the BIO Europe Spring in Stockholm from 4-6 April, the first European Drug Discovery for Neurodegeneration conference in Budapest from 15-17 May, and the BIO International Convention 2016 in San Francisco from 6-9 June.

sylics-budapest

> February 2016

The Netherlands in Shanghai: Scientific seminar on Behavioural Screening

The Holland Innovation Network, together with Noldus Information Technology and Sylics, organized a scientific seminar about Innovative technology for in vivo pharmacology and rodent behavioral phenotyping. The seminar addressed the state-of-the-art in automated behavioral screening, from the perspective of academia, contract research organizations and the pharmaceutical industry. Distinguished Chinese and Dutch speakers shared their experiences and insights, showcasing practical applications and best practices. This included innovative technologies developed in Dutch academia and biotech that are revolutionizing behavioural screening, ready for exploitation by Chinese partners. 

This week Noldus Information Technology and Sylics are visiting various companies in Shanghai active in this field, to discuss opportunities for collaboration and to expand business.

Source: https://www.facebook.com/DutchCGShanghai/

Maarten in Shanghai_2016_v2 copy

> October 2015

Sylics and Noldus combine forces for automated behavioural screening

Sylics recently signed a strategic partnership agreement with Noldus Information Technology, a company developing software and hardware for behavioural research based in Wageningen, The Netherlands. With both companies providing innovative solutions for preclinical neuroscience, this partnership opens up new opportunities for integrated and automated behavioural screening for scientists worldwide. partnership-sylics-noldus Integrated solution Noldus and Sylics combined forces and developed a complete solution consisting of PhenoTyper® home-cage monitoring, EthoVision® XT video tracking, and AHCODA™ testing protocols and cloud-based data analysis. This facilitates the 24/7 assessment of cognition, anxiety, and motor function in rodents in a home-cage environment, guarantees high quality data, and provides comprehensive graphs and statistics. New CognitionWall This partnership also entails the reselling of the CognitionWall™ by Noldus as a new add-on for the PhenoTyper home-cage. The CognitionWall was designed and validated by researchers at Sylics for sophisticated cognitive tests, such as discrimination and reversal learning. These tests can be used for rapid, sensitive, and reproducible assessment of cognitive impairments in animal models of Alzheimer’s disease and schizophrenia. Research advances PhenoTyper is an instrumented cage that can be used for home-cage testing, allowing prolonged studies and minimal or no handling of animals prior to testing. EthoVision XT software provides the tracking and activity recording of the animals, and delivers an extensive data set. For straight-forward testing (such as activity, locomotion, etc.), data selection and statistical analyses provided by EthoVision XT suffice, but for a more sophisticated analysis of rodent behaviour, AHCODA provides the ideal solution. It can be used to dissect spontaneous behaviour in great detail, evaluate cognitive function and anxiety, and other disease-specific behavioural parameters. This makes the complete solution of Noldus and Sylics particularly suited for the integral analysis of many behavioural parameters with the aim to detect behavioural effects induced by genetic mutations, chemical compounds and environmental manipulations. Examples and demonstrations Examples of research can be found at www.sylics.com and www.noldus.com. The system will also be demonstrated at Neuroscience 2015 the annual meeting of the Society for Neuroscience (Chicago, 17-21 October), as well as BIO Europe (Munich, 2-4 November).

> August 2015

Sylics and partners awarded Horizon 2020 grant

Through collaboration between outstanding European academic and industry groups, the project will improve and apply our knowledge of the comorbid basis and clinical overlap of schizophrenia, autism, and intellectual disability. In addition to the overall coordination of the project, Sylics will contribute its expertise with behavioural phenotyping and in vivo efficacy studies – in particular with testing novel compounds using our automated behavioural screening platform AHCODA.

consortium_partners

> July 2015

Meet Sylics at selected conferences in late 2015

Sylics will be present at the EBBS & EBPS Joint Meeting from 12-15 September 2015 in Verona, the Society for Neuroscience (SfN) Annual Meeting from 17-21 October 2015 in Chicago, and the BIO Europe from 2-4 November 2015 in Munich.

> June 2015

Publications: new papers on automated screening

The LightSpot test, our automated anxiety test that enables easy and standardized screening of pharmacological compounds, is now published in Behavioural Brain Research. A second paper applied our sophisticated analysis of spontaneous behaviour in an automated home-cage to evaluate within-strain variation in commonly-used mouse strains.

The light spot test: measuring anxiety in mice in an automated home-cage environment. Aarts, Loos et al., Behav Brain Res. 2015 doi: 10.1016/j.bbr.2015.06.011 Within-strain variation in behavior differs consistently between common inbred strains of mice. Loos et al., Mamm Genome. 2015 Jun 28.

> June 2015

Sylics attends the BIO Convention in Philadelphia

On 15-18 June, Sylics is present at the BIO International Convention 2015 in Philadelphia.

> May 2015

New Sylics website

We are proud to present our new website, which showcases both Sylics’ contract research services and our automated behavioural screening platform AHCODA™. > March 2015

Sylics attends the BIO Europe Spring in Paris

Sylics is available for partnering at the BIO Europe Spring 2015, held in Paris from 9-11 March.

> February 2015

Sylics present at the AD/PD 2015

Sylics is represented at the 12th International Conference on Alzheimer’s and Parkinson’s Diseases that takes place in Nice from 18-22 March. We present a novel screening protocol for automated home-cages that can be used to identify behavioural changes in mouse models of Alzheimer’s disease. Recent data show that increased amyloid-β levels lead to specific age-dependent phenotypes, making it possible to distinguish between early and late consequences of amyloid-β toxicity. These results indicate that automated screening facilitates the analysis of behaviour with high sensitivity and reproducibility and can greatly contribute to research in the field of neurodegenerative disease.

> January 2015

Publication: Novel automated operant conditioning test

Our paper describing a novel appetitive operant conditioning test for automated home-cages is accepted for publication. This test is available for our customers. Data will soon be available in our public database.

A 1-night operant learning task without food-restriction differentiates among mouse strains in an automated home-cage environment. Remmelink et al., Behav Brain Res. 2015; doi: 10.1016/j.bbr.2015.01.020

> November 2014

Sylics attends the Society for Neuroscience 2014

On 15-19 November, Sylics is present at the SfN 2014 in Washington, DC.

> November 2014

Sylics attends BIO Europe 2014

Delegates of Sylics are present at the BIO Europe conference in Frankfurt from 3-5 November.

> September 2014

Publication: Spontaneous behaviour dissected

A new publication describes the dissection of spontaneous behaviour measured in an automated home-cage into many behavioural parameters. This method facilitates a very sensitive analysis of the effects of chemical compounds and the phenotyping of novel models. Our AHCODA platform for automated analysis of spontaneous behaviour data is also available for customers. All data is published online in our public database.

Sheltering behavior and locomotor activity in 11 genetically diverse common inbred mouse strains using home-cage monitoring. Loos et al., PLoS One. 2014 9:e108563

> October 2012

Publication: novel automated avoidance learning test available

In a new publication, we present a novel avoidance learning test for automated home-cages. More information about this test is available on our website. All data can be found in our public database.

High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene. Loos et al., Genes Brain Behav. 2012; 11:772