Synaptic gene grouping and synaptic gene database (SGD)
Sylics provides functional gene group definitions for synaptic genes based on cellular functions.
SGD is established by previous protein identification, proteomic analysis, data mining and expert curation for synaptic genes and gene function. The functional gene groups defined by Sylics have been applied previously in several publications in top journals, see publications.
SGD current build 2.1 is available as a single resource (local) or as subscription (via IP).
Morphometric analyses and Tracking algorithms
Sylics is distributor for DockingDetector, Fluotracker and SynD, software packages for the Life Science market, produced in collaboration with the Functional Genomics Department of the CNCR in Amsterdam (prof. M. Verhage).
DockingDetector analyzes secretory vesicle distribution and docking in electron micrographs. The algorithm automatically detects the vesicles and calculates their distance to the plasma membrane. See Van Weering et al. 2008, >download pdf
Fluotracker detects and tracks multiple objects in living cells via Multiple Hypothesis Tracking and handles several confounds (merge/split, birth/death, and clutters). By replacing the related component (e.g. using a different appearance model) the software can be adapted for quantitative analysis of other biological samples. Fluotracker is distributed jointly with FeatureSpace, Cambridge, UK. See Broeke et al 2009, >download pdf
SynD performs automated batch analyses of morphological characteristics in immunofluorescence images of cultured neurons and reports dendrite morphology, synapse size and -number and also synaptic vesicle density, synaptic accumulation of proteins as a function of distance from the soma and detects and quantifies a wide range of neuronal organelles. See Schmitz et al. 2011, >download pdf
