Testing protocols

Automated behavioural tests

testing-protocolsThe potential of automated behavioural screening to enhance behavioural neuroscience has been described in numerous recent scientific publications. We are market leader in the development and implementation of automated behavioural testing using automated home-cages in academic and industrial settings.

Cognition, anxiety and activity

You can obtain our ready-to-use testing protocols for cognition, anxiety and activity, together with our proprietary analysis software AHCODA™, on a Pay-Per-Use basis. Our testing protocols are optimized for PhenoTyper® home-cages, produced by the Dutch company Noldus IT, market leader in video tracking software and instruments for animal behaviour research.

Development of novel tests

In addition to the existing testing protocols, we are developing novel paradigms to target even more behavioural domains. On request, we can work together with you to develop, test and validate new automated home-cage-based protocols to evaluate your animal models for psychiatric or neurological disease – contact us for more information.

Our publications on automated home-cage screening

1Cognitive flexibility deficits in a mouse model for the absence of full-length dystrophin. Remmelink, Loos et al., Genes Brain Behav. 2016; 15:558
2The light spot test: measuring anxiety in mice in an automated home-cage environment. Aarts, Loos et al., Behav Brain Res. 2015; 294:123
3Within-strain variation in behavior differs consistently between common inbred strains of mice. Loos et al., Mamm Genome. 2015; 26:348
4
A 1-night operant learning task without food-restriction differentiates among mouse strains in an automated home-cage environment. Remmelink, Loos et al., Behav Brain Res. 2015; 283:53
5Cognitive impact of cytotoxic agents in mice. Seigers, Loos et al., Psychopharmacology (Berl). 2015; 232:17
6Sheltering behavior and locomotor activity in 11 genetically diverse common inbred mouse strains using home-cage monitoring. Loos et al., PLoS One. 2014; 9:e108563
7Hyperactivity, perseveration and increased responding during attentional rule acquisition in the Fragile X mouse model. Kramvis, Loos et al., Front Behav Neurosci. 2013; 7:172
8High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene. Maroteaux, Loos et al., Genes Brain Behav. 2012; 11:772