Spontaneous behaviour

spontaneous-behaviorIn-depth analysis of spontaneous behaviour

Spontaneous home-cage behaviour is highly sensitive to detect subtle manipulations, for instance the administration of compounds, induction of gene mutations, and ageing. A thorough analysis of spontaneous behaviour is therefore a highly valuable component of preclinical efficacy and safety studies and for phenotyping of novel models. We extract a diverse set of parameters representing motor function, circadian rhythm, feeding and drinking patterns, novelty response and activity from non-manipulated, spontaneous behaviour in an automated home-cage1,2. In our standard protocol, the spontaneous behaviour of animals is recorded for 2-3 days after the initial placement in the home-cage.

Activity pattern reveals progressive motor impairment

You can follow disease progression longitudinally, by repeated assessment of spontaneous behaviour. For instance, a SOD1 mouse model of amyotrophic lateral sclerosis (ALS), a progressive motor neuron disease, shows progressive decline in several spontaneous home-cage behaviours.

1Sheltering behavior and locomotor activity in 11 genetically diverse common inbred mouse strains using home-cage monitoring. Loos et al., PLoS One. 2014; 9:e108563
2Within-strain variation in behavior differs consistently between common inbred strains of mice. Loos et al., Mamm Genome. 2015; doi: 10.1007/s00335-015-9578-7