Elevated plus maze

elevated-plus-maze2Evaluation of anxiety-like behaviour

Mice are introduced into the elevated plus maze, which contains two open and two enclosed arms. The time spent on the open arms is a measure of anxiety-related behaviour.

Genetic background affects anxiolytic response

Common inbred strains of mice differ in activity and anxiety-related behaviour. In collaboration with our partners, we studied the behaviour of a panel of these commonly used inbred strains of mice in a battery of activity/anxiety tests1.

A more detailed protocol for the elevated plus maze can be found here.

1Activity and impulsive action are controlled by different genetic and environmental factors. Loos et al., Genes Brain Behav. 2009; 8:817