Light-dark box

Light-dark-boxEvaluation of anxiety-like behaviour

Mice are introduced into the dark compartment of a light-dark box. After a delay, the motorized door opens, providing access to an identical sized compartment which is brightly lit. The time spent in the light compartment is a measure of anxiety-related behaviour.

Genetic background affects anxiolytic response

Common inbred strains of mice differ in activity and anxiety-related behaviour. In collaboration with our partners, we studied the behaviour of a panel of these commonly used inbred strains of mice in a battery of activity/anxiety tests1.

A more detailed protocol for the light-dark box can be found here.

1Activity and impulsive action are controlled by different genetic and environmental factors. Loos et al., Genes Brain Behav. 2009; 8:817