Novel cage-induced hypophagia

Evaluation of response to novelty

Prior to testing, mice are familiarized to a highly palatable snack (a few crumbs of cream cracker) placed into a familiar metal food cup in the home-cage. On the testing day novelty-induced hypophagia is assessed by transferring mice to a novel clean cage with fresh bedding containing the metal cup with the familiar snack. The latency to start eating the snack is a measure of novelty-induced hypophagia.

Novel-cage-induced-hypophagiaGenetic background affects novelty-induced hypophagia

Common inbred strains of mice differ in activity and anxiety-related behaviour. In collaboration with our partners, we studied the behaviour of a panel of these commonly used inbred strains of mice in a battery of activity/anxiety tests1.

A more detailed protocol for the novel cage-induced hypophagia test can be found here.

1Activity and impulsive action are controlled by different genetic and environmental factors. Loos et al., Genes Brain Behav. 2009; 8:817