Motor function (Spontaneous behaviour)

Automated-home-cage-based-Spontaneous-behaviorBroad analysis of motor function

Mice display a variety of spontaneous behaviours in our automated home-cages, which are tracked at high resolution with video cameras. The cages are equipped with a shelter compartment, on which mice climb during bouts of activity during the dark phase1,2. Mouse mutants with known motor function deficits, such as the SOD1 model of amyotrophic lateral sclerosis (ALS), show reduced or absent shelter climbing, an early detection of motor function deficits.

Comprehensive automated phenotyping

Especially when observations of spontaneous behaviour are combined with several other tests in the same cage, targeting different behavioural domains, a highly detailed profile of a novel mouse mutant can be generated in a matter of a few days.

More information about data on spontaneous behaviour in automated home-cages can be found here.

1Sheltering behavior and locomotor activity in 11 genetically diverse common inbred mouse strains using home-cage monitoring. Loos et al., PLoS One. 2014; 9:e108563
2Within-strain variation in behavior differs consistently between common inbred strains of mice. Loos et al., Mamm Genome. 2015; doi: 10.1007/s00335-015-9578-7