T-maze spontaneous alternation

t-maze-spontaneous-alternationEvaluation of spatial working memory

Short-term spatial memory can be assessed in a T-maze. During a sample trial, the mouse is placed in the base of the “T” to explore the maze. After an entry into one other arm, it is contained in this arm for 30 seconds by lowering a guillotine door at the entrance of the arm. During the test trial, the mouse is placed back into the start arm. A successful alternation is scored if the mouse chooses to enter the previously non-visited arm, indicating that it remembered which arm it visited before.

T-maze performance is affected in AD models

Mouse models of Alzheimer’s disease show deficits in T-maze performance, which is likely to be the result of hippocampal deficits.

A more detailed protocol for the T-maze test can be found here.