Conditioned place preference

conditioned-place-preferenceEvaluation of drug reward

The conditioned place preference (CPP) paradigm is used to evaluate the rewarding effects of a wide range of addictive drugs. A CPP setup consists of two compartments that differ in terms of tactile and visual properties, and a neutral middle compartment. After repeatedly pairing one of the two outer compartments with a drug reward (a drug injection before restricting the animal to that compartment), and pairing the other compartment with vehicle, the animal is placed into the middle compartment and its preference for each compartment is measured. Formation of a preference to spend time in the drug-paired compartment is interpreted as being mediated by the drug’s rewarding effect.

CPP can be used to assess the rewarding effects of a drug or to assess the vulnerability of a mouse strain or mutant to form drug-induced memories.