Animal use and care

Sylics complies with Dutch and European legislation to ensure animal welfare, and adheres to the replacement, reduction, and refinement principle.

Animal studies are still required in biomedical research

Studying potential therapeutics for devastating human brain diseases is critical for assessing their effectiveness. Despite many promising developments in recent years, it is not yet possible to model the complexity of a complete mammalian nervous system. Animal experiments are therefore still required to prepare potential therapies for clinical trials in patients. Sylics is dedicated to performing such preclinical effectiveness studies with the highest regard for animal welfare. All our experiments are thoroughly reviewed by an ethical committee and an animal welfare body.

C57BL/6J mouse on hand
PhenoTyper room at Sylics

Replacement, reduction, and refinement

Sylics is dedicated to improving animal welfare by adhering to the replacement, reduction, and refinement principle (3R). We only perform experiments in animals, when other model systems are insufficient to answer critical questions. Reduction has been achieved by many years of procedure optimization, which contributed to the minimization of group sizes needed for our studies. Our personnel has many years of experience with animal experimentation, which benefits the swiftness and accuracy of the biotechnical actions. Our automated home-cage-based tests significantly reduces stress caused by human-animal interaction