Automated home-cages

Automated behavioural screening in a home-cage environment

automated-home-cagesInvestigations of rodent behaviour in the context of efficacy/safety studies and behavioural phenotyping of new models strongly benefit from automated monitoring systems with 24/7 video tracking.

These systems allow the automated collection of behavioural data and the analysis of many aspects of behaviour over a range of time frames. Vast reductions in the required man-hours to conduct experiments and the automated collection, analysis and visualization of the data guarantees behavioural testing at a higher cost efficiency. Furthermore, behavioural testing in a home-cage environment, without any human intervention, reduces stress and thereby facilitates testing with high sensitivity and reproducibility.

Sylics’ automated screening tools are optimized for PhenoTyper® home-cages

Our automated testing protocols and cloud-based analysis software AHCODA™ are optimized for use with PhenoTyper® home-cages, produced by the Dutch company Noldus IT, market leader in video tracking software and instruments for animal behaviour research. Phenotypers allow continuous video tracking of rodents in a standardized environment that can be customized with a variety of add-ons, such as the CognitionWall™. Together with Sylics’ automated screening tools, these form an innovative, comprehensive and reliable basis for performing automated behavioural screens.

Our publications on automated home-cage screening

1Cognitive flexibility deficits in a mouse model for the absence of full-length dystrophin. Remmelink, Loos et al., Genes Brain Behav. 2016; 15:558
2The light spot test: measuring anxiety in mice in an automated home-cage environment. Aarts, Loos et al., Behav Brain Res. 2015; 294:123
3Within-strain variation in behavior differs consistently between common inbred strains of mice. Loos et al., Mamm Genome. 2015; 26:348
A 1-night operant learning task without food-restriction differentiates among mouse strains in an automated home-cage environment. Remmelink, Loos et al., Behav Brain Res. 2015; 283:53
5Cognitive impact of cytotoxic agents in mice. Seigers, Loos et al., Psychopharmacology (Berl). 2015; 232:17
6Sheltering behavior and locomotor activity in 11 genetically diverse common inbred mouse strains using home-cage monitoring. Loos et al., PLoS One. 2014; 9:e108563
7Hyperactivity, perseveration and increased responding during attentional rule acquisition in the Fragile X mouse model. Kramvis, Loos et al., Front Behav Neurosci. 2013; 7:172
8High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene. Maroteaux, Loos et al., Genes Brain Behav. 2012; 11:772