CognitionWall Reversal learning

Automated-home-cage-based-Reversal-learningEvaluation of cognitive flexibility

Using the CognitionWall™, we developed a four-night automated test to efficiently identify reversal learning impairments in mice, without time-consuming handling of mice. The CognitionWall is a wall with three entrances that is placed in front of a food dispenser in the automated home-cage. Mice are rewarded with a food reward when they choose to pass through one of the three entrances. After an initial discrimination learning phase, the rewarded entrance is switched to another entrance (reversal). The rate at which a mouse gains a relative preference for the newly rewarded entrance is used as a measure of reversal learning.

Comprehensive automated phenotyping

Especially when observations of reversal learning are combined with several other tests in the same cage, targeting different behavioural domains, a highly detailed profile of a novel mouse mutant can be generated in a matter of a few days.