Grip Strength Test

grip-strength-testEvaluation of neuromuscular function

Neuromuscular function is measured by the peak force a mouse can apply by grasping a bar connected to a force meter. Five trials with front paws are followed by five trials with front and hind paws combined. The median of these five trials is used as measure of grip strength.

NMJ dysfunction affects grip strength

The neuromuscular junction (NMJ) connects efferent nerves of the peripheral nervous system to muscle cells. In collaboration with our partners, we previously reported that Tomosyn-2 null mice display impaired performance in the grip strength test, in line with the essential role of Tomosyn-2 in neurotransmission at the neuromuscular junction1.

A more detailed protocol for the grip strength test can be found here.

1Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates. Geerts, Koopmans, Loos et al., Brain Struct Funct. 2014; Epub Apr 18