Sylics offers a range of services related to cannula implantations, which allows acute or chronic infusion of compounds directly into the CNS.
For testing certain compounds in preclinical studies, in particular biologicals or macromolecules such as oligonucleotides that do not cross the blood brain barrier, it is required to infuse it into the central nervous system (e.g. cerebrospinal fluid). We have experience with acute infusions directly into the ventricles in a sterotaxic frame. Alternatively, implantation of mice with brain cannulas allows for acute infusion of a compound into the brain, e.g. just before the onset of a behavioral test.
For testing certain compounds in preclinical studies, it is required to continuously infuse it into the central nervous system (e.g. cerebrospinal fluid). We have experience with implantation of mice with brain cannulas, which allowed for successful chronic continuous and intermittent infusion of the test compound into the brain. For this purpose, we also offer services with the implantation of osmotic minipumps. Please contact us for more information.
Please reach out to us if you want to learn more about our Cannula implantation solutions. We will contact you within 1 business day.