Cannula implantation

For testing certain compounds in preclinical studies, in particular biologicals or macromolecules such as oligonucleotides that do not cross the blood brain barrier, it is required to infuse it into the central nervous system (e.g. cerebrospinal fluid). We have experience with acute infusions directly into the ventricles in a sterotaxic frame. Alternatively, implantation of mice with brain cannulas allows for acute infusion of a compound into the brain, e.g. just before the onset of a behavioral test.