Neurodevelopmental disorders

tests-for-neurodevelopmental-disordersAnimal models for schizophrenia, mental retardation and autism

Neurodevelopmental disorders such as schizophrenia, mental retardation and autism are the result of a disturbed development of the central nervous system. Pathological changes on the synaptic and cellular level result in aberrant neurotransmission, network activity and behaviour.

A wide range of genes have been implicated in neurodevelopmental disorders. Using these insights from human genetic studies, genetically modified mouse lines have been created. In our hands, these lines show autism and schizophrenia-related behavioural changes, including mutant mouse lines of Tsc1, Fmr1, Pcdh9, DISC1, Neuregulin-3, Nrxn1, Cplx2 and Sap1021,2,3.

With respect to schizophrenia, the Df(h22q11)/+ and Df(h15q13)/+ models (aka 22q11 and 15q13) mimic deletions of the human orthologous genomic regions that lead to a substantial increased risk to develop schizophrenia. The 22q11 model shows robust changes in sensorimotor gating as well as subtle cognitive alterations. The 15q13 model shows changes in social behavior in the Three chamber sociability test.

 

Behavioural readouts for neurodevelopmental disorders

Behavioural tests in particular domains are instrumental for research into neurodevelopmental disorders. Sylics regularly performs tests targeting these domains, including social behaviour (Three chamber sociability test), working memory (T-maze, 8-arm radial maze), sensorimotor gating (Startle response, Prepulse inhibition), activity (MK-801-induced hyperactivity, Amphetamine-induced hyperactivity, Automated home-cage-based Dissection of activity), and executive functions (5-choice serial reaction time task (regular and automated), Simple choice reaction time task, CognitionWall Reversal learning).

Please inquire at info@sylics.com the suitability of the above models for your research question, as well as additional models.

1Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action. Loos et al., Biol Psychiatry. 2014; 76:648
2Hyperactivity, perseveration and increased responding during attentional rule acquisition in the Fragile X mouse model. Kramvis, Loos et al., Front Behav Neurosci. 2013; 7:172
3Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in Long-Term Social and Object Recognition and Sensorimotor Development. Bruining, Koopmans et al., Biol Psychiatry. 2015; DOI: http://dx.doi.org/10.1016/j.biopsych.2015.01.017