Parkinson’s disease

parkinson's-diseasePD pathology and the MPTP model

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive motor symptoms that result from a loss of dopaminergic neurons in the substantia nigra of the brain. MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a neurotoxin that is highly toxic to dopaminergic neurons in the substantia nigra. Since the discovery that MPTP induces PD symptoms in humans, MPTP-induced neurotoxicity has been one of the most widely used rodent models of PD.

Behavioural readouts for PD mouse models

The effect of MPTP treatment on motor function can be assessed in our automated home cages, as well as other tests of motor function.

Immunohistochemical analyses

To measure the loss of dopaminergic neurons, Sylics offers staining and analyses of tyrosine hydroxylase (TH) positive cells. Besides this typical IHC marker of pathology Sylics also performs analyses of neuroinflammation in this model including NLRP3 activation of the inflammasome.