Year: 2020

The ongoing COVID-19 pandemic and again rising infection numbers is affecting all of us personally and our businesses. In this situation, Sylics is focused to continue and expand our support ...

Genetic Variation in CNS Myelination and Functional Brain Connectivity in Recombinant Inbred Mice. Goudriaan A, Loos M, Spijker S, Smit AB, Verheijen MHG. Cells. 2020 Sep 18;9(9):2119. doi: 10.3390/cells9092119. PMID: ...

Tight timelines? Are you in need to have a drug screening study finished before the end of the year to comply with deadlines or your annual budget? At Sylics, we ...

In humans, the absence of the FMR1 protein leads to Fragile X syndrome, mental retardation and neurodevelopmental delays. The Fmr1 knockout mouse model is perceived as highly translational relevant due to the ...

Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons. Hoogstraaten RI, van Keimpema L, Toonen RF, Verhage M. Sci Rep. 2020 Jul 2;10(1):10913. ...

Viral Delivery of Non-Mutated Human Truncated Tau to Neurons Recapitulates Key Features of Human Tauopathy in Wild-Type Mice. Vogels T, Vargová G, Brezováková V, Quint WH, Hromádka T. J Alzheimers ...

Sylics characterized an accepted model in the field of schizophrenia research based on a microdeletion in the orthologous human 22q11.2 locus. In humans, a microdeletion of the 22q11.2 locus leads ...

Propagation of Tau Pathology: Integrating Insights From Postmortem and In Vivo Studies. Vogels T, Leuzy A, Cicognola C, Ashton NJ, Smolek T, Novak M, Blennow K, Zetterberg H, Hromadka T, ...

The outbreak of COVID-19 affects all of us worldwide in an unprecedented manner. This requires us all to prioritize care and take disruptive measures to stop spread of the virus. ...