Mouse models: Alzheimer’s disease and seeding of tau pathology

An Alzheimer’s Disease mouse model induced by ‘seeding’ of tau pathology may more closely mimic human tau pathology in comparison to transgenic tauopathy mouse models that overexpress human tau with frontotemporal dementia-linked mutations. At the SfN meeting in Chicago, together with our collaborators, we presented recent data comparing the emergence of AT8 positive Tau (see below) after seeding with various tau seeds in different mouse lines. We also investigated whether tau seeding affected cognitive performance of mice using various conventional cognitive tests as well as our automated CognitionWall test.