Publication: Molecular mechanisms of aging-associated cognitive decline

In a collaborative project, we provide evidence for the involvement of extracellular matrix levels in impairments of spatial learning in aged mice, using the Barnes maze.

_{Hippocampal extracellular matrix levels and stochasticity in synaptic protein expression increase with age and are associated with age-dependent cognitive decline. Végh, Loos et al., Mol Cell Proteomics. 2014; 13:2975}