Publication: Molecular mechanisms of aging-associated cognitive decline
Jul 7, 2014
Publication: Molecular mechanisms of aging-associated cognitive decline
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In a collaborative project, we provide evidence for the involvement of extracellular matrix levels in impairments of spatial learning in aged mice, using the Barnes maze.
Hippocampal extracellular matrix levels and stochasticity in synaptic protein expression increase with age and are associated with age-dependent cognitive decline. Végh, Loos et al., Mol Cell Proteomics. 2014; 13:2975